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            | Appraisal of the papers by our peers | Waardering van the artikelen |  
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            | A. Research on fluctuations and noise
 
 | A. Toevalsprocessen in het zenuwstelsel (Engels) 
 |  "The application of fluctuation analysis to conduction processes in excitable membranes has developed
rapidly
 since the early
work of Derksen and Verveen* (1966) on the node of Ranvier."
 Membrane Ionic Currents, Current Noise, and. Admittance in Isolated
 Cockroach Axons.
 Yves Pichon, Denis
Poussart, and Graham V. Lees, 1983
 Chapter 10 in: Chang, D.C., Tasaki, I., Adelman, W. J., and
Lenchtag,
 Structure and
Function in Excitable Cells,  H. R., Eds. Springer
  "In 1966, Verveen and Derksen* published an
intriguing investigation of
 membrane noise aimed at understanding the probabilistic behavior of
 neurons in the CNS.
 By describing a potential role for noise in computation,
 this pioneering work changed the prevalent view in biology of
 noise as a bothersome phenomenon."
 Traynelis,
S.F. & F. Jaramillo. 1998
 Getting the most out of noise in the central nervous system
 Trends in Neurosciences, 21 (4): 137-145
 
 
 "In fact, it is widely recognized that
Derksen and Verveen* changed the
 prevalent view of noise from a bothersome phenomenon to
 an essential component in biological
systems."
 Roy, S & R. Llinás. 2011
 The role of noise in brain function
 http://www.academia.edu/2294419
 * Derksen, H.E. and  A.A.
Verveen, 1966.
 Fluctuations of resting neural membrane potential.
 Science 151: 1388-1389.
 More info on this paper
 
       "it has
been well known that stochastic phenomena influence action potential
initiation since Verveen’s extensive descriptions of spike timing and threshold
fluctuations."
 Mino H.,
      J.T. Rubinstein, J.A White. 2002
      (pdf, 170 kB)
 Comparison of algorithms for the simulation of action potentials with
 stochastic sodium channels
 Annals of Biomedical Engineering, 30 (4): 578-587
 This paper refers to the role played by my Ph.D. thesis:
 Verveen, A.A. 1961. Fluctuation in excitability.
 More info
on my thesis
 
 Rubinstein,
J.T. 1995 (pdf, 1.166 kB)Threshold fluctuations in an N sodium channel model of the node of Ranvier
 Biophysical Journal 68: 779-785
 Contains an extensive discussion of our noise work done
 during the 6th and 7th decade of the former century
 
 A potential application in medicine:
 Bruce,
I.C. , M.W. White, L.S. Irlicht, S.J. O'Leary, G.M. Clark. 1999
 The effects of stochastic neural activity in a model predicting intensity
perception
 with cochlear implants: low-rate stimulation
 IEEE Transactions on Biomedical Engineering, 46(12)
 It is a great pity
that my colleague and co-worker Hans Edi Derksen died already a long time ago.
Thus, he never learned that our views on the roles of noise and chance processes
in biological systems generated a paradigm shift, are now accepted by the scientific community. 
        
          "The behaviour cycle of the Boa constrictor in captivity
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                  | The number of researchers working on the topics I am interested in is rather small. See for instance the number of articles using the work of me and my co-workers. Does the horror incerto play a role? | Het aantal onderzoekers dat in de gebieden die mij interesseren werkt is vrij klein. Kijk bijvoorbeeld naar het aantal artikelen dat van ons werk gebruik maakt. Speelt de horror incerto hierin een rol? |  
                  | B. On systems | B. Over systemen |  In my 1971 paper "In
search of processes: The early history of cybernetics" Mathematical Biosciences 11: 5-29
 a conclusion was (p. 34):
 "To muddle or to model, that is the question."
 This sentence was used as an assignment by some authors,
 and by way of an
epigraph in:
 Massoud,
T.F., G.J. Hademenos, W.L. Young, E. Gao,
 J. Pile-Spellman and F.Vinuela. 1998
 Principles and philosophy of modeling in
biomedical research
 The FASEB Journal, 1998,
12: 276-285
 
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            | C.
Snakes | C.
Slangen |  is een bijbel voor slangenhouders en -onderzoekers."
 [...] is a bible for snake keepers and snake
researchers (translation by AAV).
 bionieuws 24 (25-10-2014): p. 7
 
 Links verified: 18 January 2015
 
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